The 3 R’s: Reduce, Replace, and Refine
The scientific community has embraced the “3 R’s” philosophy about the use of animals in research since the 1959 publication of “The Principles of Humane Experimental Technique” by W. Russell and R. Burch:
Reduction
A decrease in the number of animals used while enhancing the quality of information.
Replacement
Scientifically valid substitutions for current live animal methodologies.
Refinement
Improvement that minimizes the pain, suffering, and stress of animals used in research.
Canadian universities that conduct animal-based research are required to establish detailed protocols and follow strict regulations to ensure the animals’ welfare. Increasingly, universities and other research facilities are making more use of computer simulations and reducing their use of animals.
Links
- Canadian Council on Animal Care – Three Rs
- Canadian Association for Laboratory Animal Science
- Animals in Science Policy Institute
- The Canadian Centre for Alternatives to Animal Methods (CCAAM)
- National Centre for the Replacement, Refinement & Reduction of Animals in Research
- Johns Hopkins University Center for Alternatives to Animal Testing (CAAT)
- Altweb: the Global Clearinghouse for Information on Alternatives to Animal Testing
- University of California Center for Animal Alternatives
